Dr. Ying Mei Publications
1. Hyams, N., Swagel, R., Thomas, S., Mukherjee, R., Hickman, A. B., Eldridge, D., Helke, K., Mei, Y., & Ruddy, J. M. (2025). Continuous electrocardiogram monitoring in porcine model of myocardial ischemia reperfusion. Animal Model Exp Med. https://doi.org/10.1002/ame2.70103
2. Kerr, C. M., Silver, S. E., Choi, Y. S., Floy, M. E., Bradshaw, A. D., Cho, S. W., Palecek, S. P., & Mei, Y. (2024). Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts. Bioact Mater, 31, 463-474. https://doi.org/10.1016/j.bioactmat.2023.08.023
3. Hyams, N. A., Kerr, C. M., Arhontoulis, D. C., Ruddy, J. M., & Mei, Y. (2024). Improving human cardiac organoid design using transcriptomics. Sci Rep, 14(1), 20147. https://doi.org/10.1038/s41598-024-61554-w
4. Huang, B., Coventry, B., Borowska, M. T., Arhontoulis, D. C., Exposit, M., Abedi, M., Jude, K. M., Halabiya, S. F., Allen, A., Cordray, C., Goreshnik, I., Ahlrichs, M., Chan, S., Tunggal, H., DeWitt, M., Hyams, N., Carter, L., Stewart, L., Fuller, D. H.,…Baker, D. (2024). De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15(1), 7064. https://doi.org/10.1038/s41467-024-50919-4
5. Wong, S. H., A; Gardner, W.; Chang, C.; Ying, M.; Davies, M.; Williams, P.; Alexander, M.; Ballabio, D.; Muir, B.; Winkler, D.; Pigram, P. (2023). Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF-SIMS and Self-Organizing maps. Adv Mater Interfaces, 10(9). https://doi.org/https://doi.org/10.1002/admi.202202334
6. Tan, Y., Coyle, R. C., Barrs, R. W., Silver, S. E., Li, M., Richards, D. J., Lin, Y., Jiang, Y., Wang, H., Menick, D. R., Deleon-Pennell, K., Tian, B., & Mei, Y. (2023). Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts. Sci Adv, 9(31), eadf2898. https://doi.org/10.1126/sciadv.adf2898
7. Beck, T. C., Arhontoulis, D. C., Morningstar, J. E., Hyams, N., Stoddard, A., Springs, K., Mukherjee, R., Helke, K., Guo, L., Moore, K., Gensemer, C., Biggs, R., Petrucci, T., Kwon, J., Stayer, K., Koren, N., Harvey, A., Holman, H., Dunne, J.,…Norris, R. A. (2022). Cellular and Molecular Mechanisms of MEK1 Inhibitor-Induced Cardiotoxicity. JACC CardioOncol, 4(4), 535-548. https://doi.org/10.1016/j.jaccao.2022.07.009
8. Arhontoulis, D. C., Kerr, C. M., Richards, D., Tjen, K., Hyams, N., Jones, J. A., Deleon-Pennell, K., Menick, D., Brauninger, H., Lindner, D., Westermann, D., & Mei, Y. (2022). Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries. J Tissue Eng Regen Med, 16(9), 799-811. https://doi.org/10.1002/term.3327
9. Silver, S. E., Barrs, R. W., & Mei, Y. (2021). Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy. Front Cardiovasc Med, 8, 707890. https://doi.org/10.3389/fcvm.2021.707890
10. Kerr, C. M., Richards, D., Menick, D. R., Deleon-Pennell, K. Y., & Mei, Y. (2021). Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult Myocardium. Int J Mol Sci, 22(16). https://doi.org/10.3390/ijms22168482
11. Floy, M. E., Givens, S. E., Matthys, O. B., Mateyka, T. D., Kerr, C. M., Steinberg, A. B., Silva, A. C., Zhang, J., Mei, Y., Ogle, B. M., McDevitt, T. C., Kamp, T. J., & Palecek, S. P. (2021). Developmental lineage of human pluripotent stem cell-derived cardiac fibroblasts affects their functional phenotype. FASEB J, 35(9), e21799. https://doi.org/10.1096/fj.202100523R
12. Coyle, R. C., Barrs, R. W., Richards, D. J., Ladd, E. P., Menick, D. R., & Mei, Y. (2021). Targeting HIF-alpha for robust prevascularization of human cardiac organoids. J Tissue Eng Regen Med, 15(2), 189-202. https://doi.org/10.1002/term.3165
13. Barrs, R. W., Jia, J., Ward, M., Richards, D. J., Yao, H., Yost, M. J., & Mei, Y. (2021). Engineering a Chemically Defined Hydrogel Bioink for Direct Bioprinting of Microvasculature. Biomacromolecules, 22(2), 275-288. https://doi.org/10.1021/acs.biomac.0c00947
14. Richards, D. J., Li, Y., Kerr, C. M., Yao, J., Beeson, G. C., Coyle, R. C., Chen, X., Jia, J., Damon, B., Wilson, R., Starr Hazard, E., Hardiman, G., Menick, D. R., Beeson, C. C., Yao, H., Ye, T., & Mei, Y. (2020). Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity. Nat Biomed Eng, 4(4), 446-462. https://doi.org/10.1038/s41551-020-0539-4
15. Jia, J., Jeon, E. J., Li, M., Richards, D. J., Lee, S., Jung, Y., Barrs, R. W., Coyle, R., Li, X., Chou, J. C., Yost, M. J., Gerecht, S., Cho, S. W., & Mei, Y. (2020). Evolutionarily conserved sequence motif analysis guides development of chemically defined hydrogels for therapeutic vascularization. Sci Adv, 6(28), eaaz5894. https://doi.org/10.1126/sciadv.aaz5894
16. Barrs, R. W., Jia, J., Silver, S. E., Yost, M., & Mei, Y. (2020). Biomaterials for Bioprinting Microvasculature. Chem Rev, 120(19), 10887-10949. https://doi.org/10.1021/acs.chemrev.0c00027
17. Coyle, R., Yao, J., Richards, D., & Mei, Y. (2019). The Effects of Metabolic Substrate Availability on Human Adipose-Derived Stem Cell Spheroid Survival. Tissue Eng Part A, 25(7-8), 620-631. https://doi.org/10.1089/ten.TEA.2018.0163
18. Tan, Y., Richards, D., Coyle, R. C., Yao, J., Xu, R., Gou, W., Wang, H., Menick, D. R., Tian, B., & Mei, Y. (2017). Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids. Acta Biomater, 51, 495-504. https://doi.org/10.1016/j.actbio.2017.01.029
19. Richards, D. J., Coyle, R. C., Tan, Y., Jia, J., Wong, K., Toomer, K., Menick, D. R., & Mei, Y. (2017). Inspiration from heart development: Biomimetic development of functional human cardiac organoids. Biomaterials, 142, 112-123. https://doi.org/10.1016/j.biomaterials.2017.07.021
20. Richards, D., Jia, J., Yost, M., Markwald, R., & Mei, Y. (2017). 3D Bioprinting for Vascularized Tissue Fabrication. Ann Biomed Eng, 45(1), 132-147. https://doi.org/10.1007/s10439-016-1653-z
21. Li, X., Jia, J., Mei, Y., & Latour, R. A. (2017). Molecular modeling to predict peptide accessibility for peptide-functionalized hydrogels. Biointerphases, 12(3), 031008. https://doi.org/10.1116/1.4992101
22. Richards, D. J., Tan, Y., Coyle, R., Li, Y., Xu, R., Yeung, N., Parker, A., Menick, D. R., Tian, B., & Mei, Y. (2016). Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids. Nano Lett, 16(7), 4670-4678. https://doi.org/10.1021/acs.nanolett.6b02093
23. Jia, J., Coyle, R. C., Richards, D. J., Berry, C. L., Barrs, R. W., Biggs, J., James Chou, C., Trusk, T. C., & Mei, Y. (2016). Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications. Acta Biomater, 45, 110-120. https://doi.org/10.1016/j.actbio.2016.09.006
24. Coyle, R., Jia, J., & Mei, Y. (2016). Polymer microarray technology for stem cell engineering. Acta Biomater, 34, 60-72. https://doi.org/10.1016/j.actbio.2015.10.030
25. Tan, Y., Richards, D., Xu, R., Stewart-Clark, S., Mani, S. K., Borg, T. K., Menick, D. R., Tian, B., & Mei, Y. (2015). Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells. Nano Lett, 15(5), 2765-2772. https://doi.org/10.1021/nl502227a
26. Dennis, S. G., Trusk, T., Richards, D., Jia, J., Tan, Y., Mei, Y., Fann, S., Markwald, R., & Yost, M. (2015). Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer. J Vis Exp(103). https://doi.org/10.3791/53156
27. Tan, Y., Richards, D. J., Trusk, T. C., Visconti, R. P., Yost, M. J., Kindy, M. S., Drake, C. J., Argraves, W. S., Markwald, R. R., & Mei, Y. (2014). 3D printing facilitated scaffold-free tissue unit fabrication. Biofabrication, 6(2), 024111. https://doi.org/10.1088/1758-5082/6/2/024111
28. Jia, J., Richards, D. J., Pollard, S., Tan, Y., Rodriguez, J., Visconti, R. P., Trusk, T. C., Yost, M. J., Yao, H., Markwald, R. R., & Mei, Y. (2014). Engineering alginate as bioink for bioprinting. Acta Biomater, 10(10), 4323-4331. https://doi.org/10.1016/j.actbio.2014.06.034
29. Richards, D. J., Tan, Y., Jia, J., Yao, H., & Mei, Y. (2013). 3D Printing for Tissue Engineering. Isr J Chem, 53(9-10), 805-814. https://www.ncbi.nlm.nih.gov/pubmed/26869728
30. Mei, Y. (2012). Microarrayed Materials for Stem Cells. Mater Today (Kidlington), 15(10). https://doi.org/10.1016/S1369-7021(12)70196-7
31. Hook, A. L., Chang, C. Y., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D. J., Langer, R., Anderson, D. G., Williams, P., Davies, M. C., & Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nat Biotechnol, 30(9), 868-875. https://doi.org/10.1038/nbt.2316
32. Epa, V. C., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., Davies, M. C., Alexander, M. R., & Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. J Mater Chem, 22(39), 20902-20906. https://doi.org/10.1039/C2JM34782B
33. Cho, S. W., Yang, F., Son, S. M., Park, H. J., Green, J. J., Bogatyrev, S., Mei, Y., Park, S., Langer, R., & Anderson, D. G. (2012). Therapeutic angiogenesis using genetically engineered human endothelial cells. J Control Release, 160(3), 515-524. https://doi.org/10.1016/j.jconrel.2012.03.006
34. Saha, K., Mei, Y., Reisterer, C. M., Pyzocha, N. K., Yang, J., Muffat, J., Davies, M. C., Alexander, M. R., Langer, R., Anderson, D. G., & Jaenisch, R. (2011). Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A, 108(46), 18714-18719. https://doi.org/10.1073/pnas.1114854108
35. Hook, A. L., Yang, J., Chen, X., Roberts, C. J., Mei, Y., Anderson, D. G., Langer, R., Alexander, M. R., & Davies, M. C. (2011). Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray. Soft Matter, 7(16), 7194-7197. https://doi.org/10.1039/C1SM06063E
36. Yang, J., Mei, Y., Hook, A. L., Taylor, M., Urquhart, A. J., Bogatyrev, S. R., Langer, R., Anderson, D. G., Davies, M. C., & Alexander, M. R. (2010). Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays. Biomaterials, 31(34), 8827-8838. https://doi.org/10.1016/j.biomaterials.2010.08.028
37. Yang, F., Cho, S. W., Son, S. M., Bogatyrev, S. R., Singh, D., Green, J. J., Mei, Y., Park, S., Bhang, S. H., Kim, B. S., Langer, R., & Anderson, D. G. (2010). Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A, 107(8), 3317-3322. https://doi.org/10.1073/pnas.0905432106
38. Mei, Y., Saha, K., Bogatyrev, S. R., Yang, J., Hook, A. L., Kalcioglu, Z. I., Cho, S. W., Mitalipova, M., Pyzocha, N., Rojas, F., Van Vliet, K. J., Davies, M. C., Alexander, M. R., Langer, R., Jaenisch, R., & Anderson, D. G. (2010). Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater, 9(9), 768-778. https://doi.org/10.1038/nmat2812
39. Mei, Y., Hollister-Lock, J., Bogatyrev, S. R., Cho, S. W., Weir, G. C., Langer, R., & Anderson, D. G. (2010). A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials, 31(34), 8989-8995. https://doi.org/10.1016/j.biomaterials.2010.08.029
40. Davies, M. C., Alexander, M. R., Hook, A. L., Yang, J., Mei, Y., Taylor, M., Urquhart, A. J., Langer, R., & Anderson, D. G. (2010). High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays. J Drug Target, 18(10), 741-751. https://doi.org/10.3109/1061186X.2010.521941
41. Yang, F., Mei, Y., Langer, R., & Anderson, D. G. (2009). High throughput optimization of stem cell microenvironments. Comb Chem High Throughput Screen, 12(6), 554-561. https://doi.org/10.2174/138620709788681916
42. Mei, Y., Gerecht, S., Taylor, M., Urquhart, A. J., Bogatyrev, S. R., Cho, S. W., Davies, M. C., Alexander, M. R., Langer, R. S., & Anderson, D. G. (2009). Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells. Adv Mater, 21(27), 2781-2786. https://doi.org/10.1002/adma.200803184
43. Cho, S. W., Goldberg, M., Son, S. M., Xu, Q., Yang, F., Mei, Y., Bogatyrev, S., Langer, R., & Anderson, D. G. (2009). Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells. Adv Funct Mater, 19(19), 3112-3118. https://doi.org/10.1002/adfm.200900519
44. Mei, Y., Cannizzaro, C., Park, H., Xu, Q., Bogatyrev, S. R., Yi, K., Goldman, N., Langer, R., & Anderson, D. G. (2008). Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Small, 4(10), 1600-1604. https://doi.org/10.1002/smll.200800363
45. Karnik, R., Hong, S., Zhang, H., Mei, Y., Anderson, D. G., Karp, J. M., & Langer, R. (2008). Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors. Nano Lett, 8(4), 1153-1158. https://doi.org/10.1021/nl073322a
46. Mei, Y., Goldberg, M., & Anderson, D. (2007). The development of high-throughput screening approaches for stem cell engineering. Curr Opin Chem Biol, 11(4), 388-393. https://doi.org/10.1016/j.cbpa.2007.07.006
47. Mei, Y., Elliott, J. T., Smith, J. R., Langenbach, K. J., Wu, T., Xu, C., Beers, K. L., Amis, E. J., & Henderson, L. (2006). Gradient substrate assembly for quantifying cellular response to biomaterials. J Biomed Mater Res A, 79(4), 974-988. https://doi.org/10.1002/jbm.a.30883
48. Xu, C., Wu, T., Mei, Y., Drain, C. M., Batteas, J. D., & Beers, K. L. (2005). Synthesis and characterization of tapered copolymer brushes via surface-initiated atom transfer radical copolymerization. Langmuir, 21(24), 11136-11140. https://doi.org/10.1021/la051853d
49. Wu, T., Mei, Y., Xu, C., Byrd, H. M., & Beers, K. L. (2005). Block copolymer PEO‐b‐PHPMA synthesis using controlled radical polymerization on a chip. Macromolecular rapid communications, 26(13), 1037-1042.
50. Wu, T., Mei, Y., Xu, C., & Beers, K. L. (2005). Microchip for a Kinetics Study of Controlled Polymerization Using Stoichiometry. Polymeric Materials Science and Engineering, 93.
51. Nakaoki, T., Mei, Y., Miller, L. M., Kumar, A., Kalra, B., Miller, M. E., Kirk, O., Christensen, M., & Gross, R. A. (2005). Candida antarctica lipase B catalyzed polymerization of lactones: Effects of immobilization matrices on polymerization kinetics & molecular weight. Industrial Biotechnology, 1(2), 126-134. https://doi.org/10.1089/ind.2005.1.126
52. Mei, Y., Wu, T., Xu, C., Langenbach, K. J., Elliott, J. T., Vogt, B. D., Beers, K. L., Amis, E. J., & Washburn, N. R. (2005). Combinatorial Studies of the Effect of Polymer Grafting Density on Protein Absorption and Cell Adhesion. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,
53. Mei, Y., Wu, T., Xu, C., Langenbach, K. J., Elliott, J. T., Vogt, B. D., Beers, K. L., Amis, E. J., & Washburn, N. R. (2005). Tuning cell adhesion on gradient poly(2-hydroxyethyl methacrylate)-grafted surfaces. Langmuir, 21(26), 12309-12314. https://doi.org/10.1021/la050668x
54. Mei, Y., Wu, T., Xu, C., Langenbach, K. J., Elliott, J. T., Vogt, B. D., Beers, K. L., Amis, E. J., & Washburn, N. (2005). Manipulating Cell Adhesion on Gradient Poly (2-Hydroxyethyl Methacrylate)-Grafted Surfaces.
55. Mei, Y., Wu, T., Xu, C., Langenbach, K. J., Elliott, J. T., Beers, K. L., Amis, E. J., Washburn, N. R., & Henderson, L. (2005). CONTROL OF PROTEIN ABSORPTION AND CELL ADHESION: EFFECT OF POLYMER GRAFT DENSITY. Polymer Preprints, 46(2), 1227.
56. Mei, Y., Wu, T., Xu, C., Langenbach, K. J., Elliott, J. T., Beers, K. L., Amis, E. J., Washburn, N., & Henderson, L. (2005). Control of Protein Absorption and Cell Adhesion: Effect of Polymer Grafting Density.
57. Wu, T., Mei, Y., Xu, C., & Beers, K. (2004). Phase transition of PDMAEMA-b-PEG in aqueous solution dependence on molecular weights and compositions. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,
58. Wu, T., Mei, Y., Cabral, J. T., Xu, C., & Beers, K. L. (2004). A new synthetic method for controlled polymerization using a microfluidic system. J Am Chem Soc, 126(32), 9880-9881. https://doi.org/10.1021/ja048432n
59. Wu, T., Mei, Y., Cabral, J., Xu, C., & Beers, K. L. (2004). A New Synthetic Method for Controlled Polymerization of HPMA Using a Microfluidic System.
60. Mei, Y., Kumar, A., Gao, W., Gross, R., Kennedy, S. B., Washburn, N. R., Amis, E. J., & Elliott, J. T. (2004). Biocompatibility of sorbitol-containing polyesters. Part I: Synthesis, surface analysis and cell response in vitro. Biomaterials, 25(18), 4195-4201. https://doi.org/10.1016/j.biomaterials.2003.10.087
61. Mei, Y., Beers, K. L., Byrd, H. C., VanderHart, D. L., & Washburn, N. R. (2004). Solid-phase ATRP synthesis of peptide-polymer hybrids. J Am Chem Soc, 126(11), 3472-3476. https://doi.org/10.1021/ja039583d
62. Mei, Y., Miller, L., Gao, W., & Gross, R. A. (2003). Imaging the distribution and secondary structure of immobilized enzymes using infrared microspectroscopy. Biomacromolecules, 4(1), 70-74. https://doi.org/10.1021/bm025611t
63. Mei, Y., Kumar, A., & Gross, R. (2003). Kinetics and Mechanism of Candida a Ntarctica Lipase B Catalyzed Solution Polymerization of ε-Caprolactone. Macromolecules, 36(15), 5530-5536.
64. Mei, Y., Kumar, A., Gao, W., Gross, R., Kennedy, S., Washburn, N., & Amis, E. (2003). Biocompatibility studies of sorbitol-containing polyesters. I. Synthesis, surface analysis and cell response in vitro. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,
65. Mei, Y. (2003). Mechanism and applications of Novozyme435-catalyzed polyesters synthesis Polytechnic University].
66. Kennedy, S. B., Mei, Y., Gross, R., Washburn, N., & Amis, E. J. (2003). Quantifying Cell-Response to Materials Through Population Analyses Enabled by High-Throughput Techniques.
67. Mei, Y., Kumar, A., & Gross, R. A. (2002). Probing water-temperature relationships for lipase-catalyzed lactone ring-opening polymerizations. Macromolecules, 35(14), 5444-5448.